Cold Laser Therapy for Knee Osteoarthritis
Cold Laser Therapy for Knee Osteoarthritis
Non-invasive, evidence-based photobiomodulation for knee pain — supported by 22 placebo-controlled trials involving 1,063 participants
Who gets knee osteoarthritis?
Knee osteoarthritis is one of the most common joint conditions in Australia. It does not discriminate – it affects retirees, office workers, tradies and weekend athletes alike. The common thread is a knee joint under load, whether from decades of activity, prolonged sitting, or heavy physical work.
Tap the one that sounds like you.
Retirees & Older Adults
Stiffness, stairs, swelling
Active Adults & Weekend Warriors
Running, cycling, post-exercise ache
Office & Desk Workers
Desk stiffness, commute pain
Tradies & Physical Workers
Kneeling, ladders, concrete
How Photobiomodulation May Help Knee Osteoarthritis
How it works at a cellular level
Photobiomodulation works by delivering specific wavelengths of light energy into the tissues surrounding the knee joint. At the cellular level, this light energy is absorbed by chromophores — primarily cytochrome c oxidase in the mitochondria — which may trigger a cascade of biological responses:
- Pain modulation — PBM may influence inflammatory mediators and nerve signalling pathways, potentially reducing the perception of pain at the joint
- Reduced inflammation — Studies suggest PBM may help modulate the inflammatory response in osteoarthritic joints
- Improved cellular metabolism — Enhanced mitochondrial function may support tissue repair processes in the structures surrounding the joint
- Improved function — Multiple trials report improvements in daily function measures alongside pain reduction
Important context
Knee osteoarthritis involves a complex interplay of cartilage degradation, inflammation, subchondral bone changes and muscular weakness. Photobiomodulation does not reverse cartilage loss, but research suggests it may help manage the pain and functional limitations that accompany the condition.
The meta-analysis identified a clear dose-response relationship: 4–8 J at 785–860 nm wavelength and 1–3 J at 904 nm wavelength per treatment spot produced the strongest results. Our Multi-Radiance MR5 ACTIV PRO delivers wavelengths within both of these optimal ranges (905nm super-pulsed laser and 875nm infrared).
Individual responses to photobiomodulation therapy vary. Results depend on factors including the severity of the condition, treatment parameters used, and individual biology. A thorough clinical assessment is recommended before commencing any treatment plan.
The Evidence Base
22 placebo-controlled RCTs, 1,063 participants, published in BMJ Open
Stausholm et al. 2019 — BMJ Open Meta-Analysis (1,063 patients)
The largest placebo-controlled analysis of cold laser therapy for knee osteoarthritis to date. Involving 1,063 participants across 22 randomised controlled trials, this study found that photobiomodulation significantly reduced pain compared to placebo. When recommended treatment parameters were used, pain reduction peaked at 2–4 weeks after completing therapy — a 31.87 mm reduction on the Visual Analogue Scale beyond placebo (95% CI 18.18–45.56). Disability was also significantly reduced. No adverse events were reported in any trial.
This is a summary of published research findings. Individual treatment outcomes vary and are not guaranteed.
PMID: 31662383 • DOI: 10.1136/bmjopen-2019-031142
Oliveira et al. 2024 — Physical Therapy Meta-Analysis (542 patients)
A more recent analysis involving 542 participants across 10 placebo-controlled RCTs found that photobiomodulation significantly reduced pain at rest compared to placebo, with a moderate effect size (SMD -0.7, 95% CI -1.1 to -0.2). The authors concluded that PBM may complement other widely recommended therapies for knee osteoarthritis, including exercise.
Individual responses vary. This study’s results may not predict your personal outcome.
PMID: 38775202 • DOI: 10.1093/ptj/pzae073
“LLLT reduces pain and disability in KOA at 4–8 J with 785–860 nm wavelength and at 1–3 J with 904 nm wavelength per treatment spot.”
Stausholm et al., BMJ Open, 2019 (PMID 31662383)
Our clinical device delivers wavelengths and energy densities within the ranges that produced the strongest positive outcomes in this meta-analysis. Individual responses vary.
Ready to explore cold laser therapy?
$99 initial consultation includes full assessment and first treatment session. No lock-in plans.
What to Expect
Your first visit ($99)
- Assessment — Dr Sam Johnson (Chiropractor) will conduct a thorough assessment of your knee, including range of motion, functional tests and a review of your history. This helps determine whether photobiomodulation is appropriate for your presentation.
- Treatment parameters — If cold laser therapy is indicated, treatment parameters are selected based on the evidence. For knee osteoarthritis, research supports specific wavelengths (785–904 nm) and energy doses (1–8 J per spot) depending on the tissue depth.
- The treatment — The Multi-Radiance MR5 ACTIV PRO (ARTG-listed, 370913) is applied to the knee. Treatment is painless. Most people feel a gentle warmth or nothing at all. A typical knee session takes approximately 10–15 minutes.
- Your plan — Based on the assessment findings, Dr Johnson will discuss whether a course of treatment may be appropriate. The evidence suggests that results for knee osteoarthritis are typically observed over a course of sessions rather than a single visit. There are no lock-in plans. The decision is always yours.
Ongoing care
- Treatment sessions are typically 10–15 minutes including setup
- Research protocols showing positive outcomes used multiple sessions per week
- Pain reduction peaked 2–4 weeks after completing a treatment course (Stausholm 2019)
- Ongoing care options are discussed at your initial consultation
- On the Marion Road commuter corridor — convenient before or after work from Plympton Park, Plympton, Park Holme, Glenelg North, Morphettville, Edwardstown, Ascot Park, and Marion
Treatment frequency and duration are individualised based on your clinical presentation and response. The figures above reflect protocols used in published research studies.
⚠️ When to See Your GP Urgently
While knee osteoarthritis is common and generally manageable, certain symptoms warrant prompt medical attention:
- Sudden, severe knee swelling with warmth and redness — may indicate infection or gout requiring urgent assessment
- Inability to bear weight on the leg after an injury — could indicate a fracture or ligament rupture
- Knee locking or giving way repeatedly — may indicate a loose body or meniscal tear requiring investigation
- Fever alongside knee pain and swelling — septic arthritis requires emergency treatment
- Unexplained weight loss combined with persistent joint pain — while rare, these require investigation to rule out other conditions
If you are unsure whether your symptoms are urgent, please contact your GP or call 13 HEALTH (13 43 25 84) for advice.
Frequently Asked Questions
Will cold laser therapy fix my knee osteoarthritis?
Photobiomodulation does not reverse cartilage loss or cure osteoarthritis. What the research suggests is that it may help reduce pain and improve daily function. A meta-analysis of 22 trials found significant pain reductions, particularly when recommended treatment parameters were used. Think of it as a tool that may help you move more comfortably and do more of the things you enjoy. Individual responses vary.
Does the laser treatment hurt?
No. Most people feel a gentle warmth or nothing at all during treatment. The Multi-Radiance MR5 ACTIV PRO uses super-pulsed technology, which delivers therapeutic energy without heating the skin surface. There is no recovery time and you can return to normal activities immediately.
How many sessions will I need?
The evidence for knee osteoarthritis suggests that results are typically observed over a course of treatment rather than a single session. The largest meta-analysis found that pain reduction peaked 2–4 weeks after completing a treatment course. During your first visit, Dr Sam Johnson (Chiropractor) will assess your situation and discuss what may be appropriate. There are no lock-in plans at Adelaide Cold Laser.
Can I still exercise with knee osteoarthritis?
Exercise is one of the most important things you can do for knee osteoarthritis. Guidelines from the Royal Australian College of General Practitioners recommend exercise as a first-line approach. Photobiomodulation may complement your exercise routine by potentially helping manage pain, which may make movement easier. We can discuss what types of activity may be suitable based on your assessment.
How much does cold laser therapy cost at Adelaide Cold Laser?
Your first visit is $99, which includes a thorough assessment and treatment where clinically appropriate. Ongoing care options are discussed at your initial consultation. No lock-in plans. If you prepay for sessions you do not end up using, we refund them in full. The decision is always yours.
Is cold laser therapy covered by private health insurance?
Cold laser therapy delivered by a registered chiropractor is typically claimable under chiropractic extras cover with most private health funds. We provide a receipt after each visit for you to claim via your fund’s app. Check with your fund regarding your specific level of cover.
Do I need a referral?
No. Chiropractors are primary contact practitioners in Australia. You can book directly without a referral from your GP. If you have a GP Management Plan (EPC plan), you may be eligible for a partial Medicare rebate.
I have already tried everything for my knee — why would this be different?
Photobiomodulation works through a different mechanism to most other treatments. It delivers specific wavelengths of light to the tissues, which may influence cellular processes at the mitochondrial level. This is different to medication (which targets pain pathways systemically), cortisone injections (which suppress local inflammation), or exercise (which strengthens surrounding structures). Research suggests that cold laser therapy may be most effective when used alongside other approaches as part of a broader management plan. Individual responses vary.
What is the evidence for cold laser therapy for knee osteoarthritis?
The evidence base for knee OA is one of the strongest in the photobiomodulation field. A 2019 meta-analysis published in BMJ Open analysed 22 placebo-controlled randomised trials involving 1,063 participants and found statistically significant pain reductions. A more recent 2024 analysis in Physical Therapy confirmed these findings with a moderate effect size. Both studies reported no adverse events. The World Association for Laser Therapy has published specific treatment parameter recommendations based on this evidence.
Is cold laser therapy safe?
Photobiomodulation has an excellent safety profile. Across the 22 knee OA trials in the largest meta-analysis, no adverse events were reported. The Multi-Radiance MR5 ACTIV PRO is listed on the Australian Register of Therapeutic Goods (ARTG 370913). A 2025 international expert consensus confirmed that red and near-infrared light PBM does not induce DNA damage. Cold laser therapy is not appropriate during pregnancy over the abdomen, directly over active cancers, or over the eyes without appropriate protection.
Is knee osteoarthritis the same as wear and tear?
“Wear and tear” is a common description but does not fully capture what is happening. Osteoarthritis involves an active process including inflammation, changes to the bone beneath the cartilage, and alterations to the joint capsule and surrounding muscles. It is not simply a matter of the joint wearing out. Understanding this is important because it means there are multiple targets for management — not just the cartilage itself.
Does the severity of my osteoarthritis affect whether cold laser therapy will help?
The clinical trials have included participants with a range of osteoarthritis severity. The largest meta-analysis included participants meeting American College of Rheumatology criteria, which covers mild to severe presentations. However, individual responses vary. During your assessment, Dr Sam Johnson will evaluate your presentation and discuss whether cold laser therapy is likely to be appropriate for your level of severity.
What device do you use?
We use the Multi-Radiance MR5 ACTIV PRO, a super-pulsed laser listed on the Australian Register of Therapeutic Goods (ARTG 370913). It delivers multiple wavelengths simultaneously — including 905 nm super-pulsed laser, 875 nm infrared, and 640 nm red light — which research suggests may optimise tissue penetration and therapeutic effect. This is the same class of device used in many of the clinical trials referenced on this page.
Can cold laser therapy delay the need for knee replacement surgery?
Research has not specifically addressed whether photobiomodulation delays knee replacement surgery. What the evidence does suggest is that it may help reduce pain and improve function, which may allow some people to manage their symptoms more effectively. Any decisions about surgery should be made in consultation with your orthopaedic surgeon. Photobiomodulation is a complementary approach, not a replacement for surgical assessment when indicated.
Other Conditions We May Help With
Questions? We’re here to help.
Call us on (08) 8297 5277 or book online — no obligation.
Book a Consultation
$99 initial consultation includes full clinical assessment and first treatment session.
No lock-in plans. The decision is always yours.
(08) 8297 5277 • 528 Marion Road, Plympton Park SA 5038
Mon–Fri 7am–7pm • Sat 8am–12pm
References
- Stausholm MB et al. (2019). Efficacy of low-level laser therapy on pain and disability in knee osteoarthritis: systematic review and meta-analysis of randomised placebo-controlled trials. BMJ Open, 9(10):e031142. PMID: 31662383
- Oliveira S et al. (2024). Effectiveness of Photobiomodulation in Reducing Pain and Disability in Patients With Knee Osteoarthritis: A Systematic Review With Meta-Analysis. Physical Therapy, 104(8). PMID: 38775202
- Maghfour J et al. (2025). Evidence-based consensus on the clinical application of photobiomodulation. Journal of the American Academy of Dermatology, 93(2):429-443. PMID: 40253006
About Adelaide Cold Laser
Practitioner: Dr Sam Johnson (Chiropractor), BSc(Chiro), MChiro — Macquarie University
Practice: Adelaide Cold Laser • 528 Marion Road, Plympton Park SA 5038
Phone: (08) 8297 5277 • Email: wecanhelp@stapletonchiropractic.com.au
Hours: Monday to Friday 7:00am – 7:00pm • Saturday 8:00am – 12:00pm
Pricing: $99 initial consultation • Private pay • No referral required
The information on this page is provided for general educational purposes and is not intended as medical advice. It describes findings from published peer-reviewed research and should not be interpreted as a guarantee or promise of any particular treatment outcome. Individual responses to photobiomodulation therapy vary. Not all patients will experience the results described in published studies.
Dr Sam Johnson (Chiropractor) will conduct a thorough clinical assessment before recommending any treatment approach. If you are experiencing knee pain, please consult a qualified healthcare practitioner for personalised advice.
All clinical claims on this page are supported by referenced peer-reviewed research. Study citations include PubMed identifiers (PMIDs) for independent verification.
Adelaide Cold Laser uses a clinical-grade super-pulsed laser device listed on the Australian Register of Therapeutic Goods (ARTG 370913).



